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  • Title: Further assessment of benzodiazepine-tricyclic antidepressant interaction. Effectiveness of combined treatment with ketazolam-nortriptyline on conflict behaviour in rats.
    Author: Cannizzaro G, Brucato AF, Provenzano PM.
    Journal: Arzneimittelforschung; 1982; 32(9):1111-3. PubMed ID: 6128985.
    Abstract:
    Using Geller and Seifter's conflict behaviour test, ketazolam in rat increases the rate of responses emitted both with and without punishment. Nortriptyline decrease the non-punished component of the schedule without influencing the punished one. With combined treatment, nortriptyline does not modify the effects of ketazolam on punished responses while nortriptyline, 1 h after administration, decreases, though not significantly, the facilitating action of ketazolam. After 24 h it significantly increases the depressant action of this benzodiazepine. The results suggest that with the combination tricyclic anti-depressant-benzodiazepine, as with these two categories of drugs, there is not always an increase in disinhibiting action, while depressant action has characteristics closely dependent on the properties of the benzodiazepine used.
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