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  • Title: Hematopoietic microenvironment transfer by stromal fibroblasts derived from bone marrow varying in cellularity.
    Author: Patt HM, Maloney MA, Flannery ML.
    Journal: Exp Hematol; 1982 Oct; 10(9):738-42. PubMed ID: 6129153.
    Abstract:
    Autologous fibroblast derivatives of red and yellow marrow of rabbits were shown to differ in their capability to transfer a hematopoietic microenvironment upon implantation under the renal capsule. Although a heterotopic ossicle formed in each instance, the quality of the associated medullary tissue mirrored the quality of the bone marrow used to generate the stromal fibroblasts. Thus, fibroblasts cultured from a cellular marrow produced a stroma with numerous hematopoietic foci whereas those cultured from a severely hypocellular marrow produced a stroma with mainly fat cells. The results with 21 implants point to a transmittable regulatory role of a class of stromal fibroblasts.
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