These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: The failing brain.
    Author: Bowen DM, Davison AN.
    Journal: J Chronic Dis; 1983; 36(1):3-13. PubMed ID: 6129258.
    Abstract:
    In the elderly, loss of brain wet weight and reduction in neuronal populations may be related to declining cognitive function. In some brain areas there appear to be reduced dendritic arborization. In the aging brain, neurotransmitter metabolism is affected. Catecholamine concentration appears to be especially reduced. More marked loss of cells and synapses is seen in senile dementia of the Alzheimer's type, and there is a significant reduction in choline acetyltransferase activity and in the ability of isolated biopsy tissue to synthesise acetylcholine. The significance of these findings and the possibility of drug intervention is discussed.
    [Abstract] [Full Text] [Related] [New Search]