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  • Title: Inhibition by enkephalins of peristaltic activity of the rabbit ileum and its reversal by naloxone.
    Author: Beleslin DB, Terzić B.
    Journal: J Pharm Pharmacol; 1982 Nov; 34(11):738-9. PubMed ID: 6129308.
    Abstract:
    Two pentapeptides, the enkephalins have been isolated and identified from the mammalian gastrointestinal tract and have been shown to be potent opiate agonists (Hughes 1975; Lord et al 1977; Hughes et al 1977). Further work has demonstrated that methionine (met-)-enkephalin and D-Ala2-Leu-enkephalinamide affected the peristaltic reflex of the guinea-pig isolated ileum (van Nueten et al 1977; Kromer et al 1980). On the other hand, the rabbit isolated ileum has been scarcely used as model to study the peristaltic reflex (Feldberg & Lin 1949; Beleslin et al 1978). However, after evidence of the existence of met- and leucine (leu)-enkephalin as well as of enkephalin receptors in the rabbit intestine was reported (Hughes et al 1977; Oka 1980) it became interesting to investigate the action of enkephalins on the peristaltic activity of rabbit isolated ileum.
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