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  • Title: Synthesis of chick brain GABA receptors by frog oocytes.
    Author: Miledi R, Parker I, Sumikawa K.
    Journal: Proc R Soc Lond B Biol Sci; 1982 Nov 22; 216(1205):509-15. PubMed ID: 6129641.
    Abstract:
    Poly(A)-mRNA, extracted from the optic lobe of chick embryos, directs the synthesis of gamma-aminobutyric acid (GABA) receptors in Xenopus laevis oocytes. The receptors are inserted into the oocyte membrane, where they form receptor--channel complexes. When activated by GABA, and related agonists, the chick brain receptors open membrane channels that are permeable to chloride ions. Thus, Xenopus oocytes provide a novel and useful approach to the study of brain receptors.
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