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  • Title: Peripheral alpha 1- and alpha 2-adrenoreceptor mechanisms in blood pressure control.
    Author: Reid JL, Hamilton CA, Hannah JA.
    Journal: Chest; 1983 Feb; 83(2 Suppl):302-4. PubMed ID: 6129947.
    Abstract:
    Peripheral alpha-adrenoreceptors can be characterized as alpha 1 or alpha 2, depending on their affinity for agonists and antagonists. Alpha 2-adrenoreceptors, probably located postsynaptically on smooth muscle of resistance vessels, contribute to the pressor responses to intravenously given norepinephrine. Studies with the noncompetitive alpha-adrenoreceptor antagonist phenoxybenzamine suggest that there are important differences in the regulation of the two types of receptors. The slower recovery alpha 1-adrenoreceptor binding sites and the more rapid recovery of responses suggest the presence of "spare" alpha 1- but not alpha 2-adrenoreceptors.
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