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  • Title: [Prevention and therapy of delirium tremens with tiapride and chlordesmethyldiazepam].
    Author: Cazzato G, Gioseffi M, Torre P, Coppola N.
    Journal: Riv Neurol; 1982; 52(6):331-42. PubMed ID: 6130594.
    Abstract:
    Forty alcohol abusers (with a history of long-time alcohol addiction and mean daily use over 360 grams of alcohol) were treated with tiapride or chlordesmethyldiazepam when stopped their overdrinking. The aim of such pharmacological treatment was both a valuation of effectiveness towards ten target-symptoms and the attempt to avoid the development of a withdrawal syndrome-or, at least, to shorten its course. Chlordesmethyldiazepam resulted to be on the whole more effective than tiapride in dominating all most dramatic symptoms of Delirium Tremens and in avoiding--in a significantly higher number of patients--the onset of a DT syndrome in all its typical features. Moreover, CDDz appeared as a manageable drug and free from important side-effects, and could control symptoms without need of further therapies.
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