These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Antisickling effects of membrane-interacting compounds.
    Author: Ohnishi ST.
    Journal: Blood Cells; 1982; 8(2):337-43. PubMed ID: 6130805.
    Abstract:
    Several anti-psychotic drugs were found to have an in vitro antisickling effect. A linear relationship was found between the antisickling activity and the inhibition of calmodulin stimulated phosphodiesterase activity. These membrane-interacting compounds produce a "cup-shaped" red blood cell at the concentration where they demonstrate an antisickling effect. The volume of a "cup-shaped" red cell (with chlorpromazine) does not change significantly from that of an untreated control red cell. The anti-sickling mechanism of these membrane-interacting compounds is not known at this point.
    [Abstract] [Full Text] [Related] [New Search]