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  • Title: Desipramine hydroxylation: variability and effect of antipsychotic drugs.
    Author: Bock JL, Nelson JC, Gray S, Jatlow PI.
    Journal: Clin Pharmacol Ther; 1983 Mar; 33(3):322-8. PubMed ID: 6130865.
    Abstract:
    Steady-state plasma concentrations of desipramine (DMI), unconjugated 2-OH DMI, and total 2-OH DMI were measured in 82 depressed inpatients, 35 of whom were concurrently receiving a phenothiazine or butyrophenone antipsychotic drug. In the patients not on an antipsychotic, the ratio of unconjugated metabolite to parent varied from 0.01 to 1.5, with a median of 0.48, and was inversely related to the parent drug level. Antipsychotic drug was associated with higher DMI levels and a lower proportion of OH-metabolite (median, 0.23). In both groups the unconjugated form accounted for only about 10% of the total metabolite. No relationship of age, sex, drinking history, or smoking to DMI or 2-OH DMI levels was found.
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