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  • Title: Regulation of the pineal melatonin concentration in the rat (Rattus norvegicus) and in the Djungarian hamster (Phodopus sungorus).
    Author: Illnerová H, Vanĕcek J, Hoffmann K.
    Journal: Comp Biochem Physiol A Comp Physiol; 1983; 74(1):155-9. PubMed ID: 6130878.
    Abstract:
    1. Rapid changes of melatonin concentration in pineals of rats (Rattus norvegicus) after isoproterenol administration or in the course of a day were accompanied by parallel changes of N-acetyltransferase but not of hydroxyindole-O-methyltransferase activity. 2. In pineals of Djungarian hamsters (Phodopus sungorus) the evening and morning melatonin changes were also parallel with N-acetyltransferase changes. 3. In both species, melatonin concentration during its rise had approached the maximum earlier than N-acetyltransferase reached its highest activity. 4. It is proposed that the N-acetyltransferase rhythm drives the melatonin rhythm both in rats and in Djungarian hamsters; the maximum melatonin production may, however, depend also on hydroxyindole-O-methyltransferase activity and substrate concentration.
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