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  • Title: Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols.
    Author: Diamond GL, Anders MW, Tremaine LM, Quebbemann AJ.
    Journal: Drug Metab Dispos; 1982; 10(6):573-8. PubMed ID: 6130902.
    Abstract:
    Salicylate administration increased glucuronyltransferase activity, with o-aminophenol as the substrate, in chicken kidney homogenates, but did not affect glucuronyltransferase activity in chicken liver homogenates. In addition, salicylate administration increased in vivo renal glucuronidation of catechol and p-nitrophenol without affecting renal sulfate conjugation of these compounds. These results suggest that salicylate administration selectively enhances renal glucuronide conjugation, thereby promoting a more rapid metabolism and elimination of circulating phenols, especially at high plasma phenol concentrations. Isolated human kidney perfusion experiments reveal that glucuronide and sulfate conjugates of phenol, p-nitrophenol, and 1-naphthol are formed in the human kidney, suggesting that the effect of salicylate treatment on renal glucuronidation may apply to humans.
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