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  • Title: [Respiratory stimulant effect of S 2620 in the dog anesthetized with pentobarbital].
    Author: Gastaud M, Dolisi C, Camous JP, Gibelli A, Ripoll B, Ardisson JL.
    Journal: C R Seances Soc Biol Fil; 1975; 169(6):1579-84. PubMed ID: 6131.
    Abstract:
    In the dog under pentobarbitone anesthesia, the intravenous injection of 1 mg/kg S 2620 is followed by a significant increase in respiratory rate, PaO2 and pHa and by a large decrease in PaCO2. Cervical vagotomy and chemoreceptor denervation reduced and even abolished these effects. They can be induced again by a second intravenous injection or by direct instillation in the fourth ventricle. These results suggest a central action of the drug.
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