These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


Pubmed for Handhelds

PUBMED FOR HANDHELDS

Search MEDLINE/PubMed

  • Title: Analgesia produced by microinjection of L-glutamate into the rostral ventromedial bulbar nuclei of the rat and its inhibition by intrathecal alpha-adrenergic blocking agents.
    Author: Satoh M, Oku R, Akaike A.
    Journal: Brain Res; 1983 Feb 21; 261(2):361-4. PubMed ID: 6131729.
    Abstract:
    Definite and dose-dependent analgesia followed microinjection of L-glutamate into the nucleus reticularis paragigantocellularis (NRPG) of rats. This analgesic effect was inhibited by lumbar intrathecal pretreatment with phenoxybenzamine and phentolamine but not by propranolol, methysergide or naloxone. Microinjection of L-glutamate into the nucleus raphe magnus (NRM) also produced an analgesic effect which was reduced by intrathecal pretreatment with methysergide but not by phentolamine. These findings provide direct evidence that the NRPG and NRM function separately in descending pain-suppression systems of the spinal cord.
    [Abstract] [Full Text] [Related] [New Search]