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  • Title: Trypsin activation of the red cell Ca2+-pump ATPase is calcium-sensitive.
    Author: Rossi JP, Schatzmann HJ.
    Journal: Cell Calcium; 1982 Dec; 3(6):583-90. PubMed ID: 6131745.
    Abstract:
    Stimulation of the calmodulin-independent activity of the red cell Ca2+-pump ATPase by trypsin treatment (of calmodulin free red cell membranes) is sensitive to Ca2+ in a concentration range near the KCa of the transport site. The Ca2+ requirement for this effect is absolute, whereas the calmodulin sensitivity of the ATPase can be abolished by sufficient trypsin attack in the absence of Ca2+, although Ca2+ accelerates inactivation. This indicates that the two effects of trypsin are due to at least two distinct cleavage sites in the pump protein.
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