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  • Title: Comparison of quazepam, flunitrazepam and placebo as single-dose hypnotics before surgery.
    Author: Wickstrøm E, Allgulander C.
    Journal: Eur J Clin Pharmacol; 1983; 24(1):67-9. PubMed ID: 6131825.
    Abstract:
    The hypnotic effect and tolerance of quazepam (Sch 16134) 15 and 30 mg, flunitrazepam 1 and 2 mg and placebo were evaluated in a one-night, randomized, double-blind, parallel group study of 100 hospitalized patients, who were to undergo a planned operation on the following day. All active drugs were rated as superior to placebo by the physician. Subjectively, quazepam 30 mg and flunitrazepam 1 and 2 mg were superior to placebo. Hangover effects were not distinguishable from placebo. Vigilance and ataxia tests were not altered by any of the drugs.
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