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  • Title: Dependence on benzodiazepines.
    Author: Lader M.
    Journal: J Clin Psychiatry; 1983 Apr; 44(4):121-7. PubMed ID: 6131885.
    Abstract:
    Psychotropic drugs are widely prescribed and tend to be used on a long-term basis. The barbiturates are known to induce tolerance and dependence, with a well-defined and often severe withdrawal syndrome from high doses. By contrast, the benzodiazepines are infrequently associated with tolerance and dependence at high doses. Recent work, however, has suggested that a definite withdrawal syndrome can supervene on discontinuation of long-term normal doses of benzodiazepines. In view of the widespread and chronic use of the benzodiazepines, this may represent a major problem. The theoretical implications of such normal-dose dependence are discussed.
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