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  • Title: Midazolam: dose-response studies of effectiveness and rebound insomnia.
    Author: Kales A, Soldatos CR, Bixler EO, Goff PJ, Vela-Bueno A.
    Journal: Pharmacology; 1983; 26(3):138-49. PubMed ID: 6132414.
    Abstract:
    Midazolam, an investigational hypnotic, was evaluated for effectiveness, side effects, and withdrawal phenomena in doses of 10, 20, and 30 mg in three separate sleep laboratory studies, each including 4 placebo-baseline nights, 7 drug nights, and 3 placebo-withdrawal nights. Only a slight to moderate degree of effectiveness was shown across the three doses; this effectiveness was much more pronounced during the first third of the night. There was no dose-response effect for effectiveness with either initial or continued drug administration. In general, there was less effectiveness on the last 3 drug nights, indicating a potential for the development of tolerance over a relatively short period of time. Following withdrawal there was a marked dose-related worsening of sleep above baseline levels (rebound insomnia).
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