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  • Title: Comparison of pharmacological and binding assays for ten beta-adrenoceptor blocking agents and two beta-adrenoceptor agonists.
    Author: Bieth N, Rouot B, Schwartz J, Velly J.
    Journal: Br J Pharmacol; 1980 Mar; 68(3):563-9. PubMed ID: 6132636.
    Abstract:
    1 The inhibition constants evaluated by binding assays for ten beta-adrenoceptor blocking agents and two beta-adrenoceptor agonists, were compared with the pA2 and pD2 values determined in vitro and in vivo. 2 There was only a limited correlation between beta 1 or beta 2 selectivities observed with the different methods. 3 Selectivity is generally less pronounced in binding assays than for in vivo and in vitro experiments.
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