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  • Title: Enhancement of rectal absorption of insulin using salicylates in dogs.
    Author: Nishihata T, Rytting JH, Kamada A, Higuchi T, Routh M, Caldwell L.
    Journal: J Pharm Pharmacol; 1983 Mar; 35(3):148-51. PubMed ID: 6132970.
    Abstract:
    Sodium salicylate and 5-methoxysalicylate both increased the rectal absorption of insulin in dogs when co-administered with insulin in various formulations. Microenema formulations containing 4% gelatin showed the highest insulin bioavailability of the formulations studied whereas microenemas (without gelatin) and suppository formulations were not as effective in enhancing the rectal absorption of insulin.
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