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  • Title: Selective antagonist activity of 5-aminohex-2-enedioic acid on amino acid excitation of cat spinal neurones.
    Author: Allan RD, Bornstein JC, Curtis DR, Johnston GA, Lodge D.
    Journal: Neurosci Lett; 1980 Jan; 16(1):17-20. PubMed ID: 6133238.
    Abstract:
    D- and L-5-aminohex-2-enedioic acid (AHED) and the DL-2-bromo derivative, which are conformationally restricted analogues of the excitatory amino acid antagonist D-alpha-aminoadipic acid (D alpha AA), were tested microelectrophoretically on cat spinal neurones. D-AHED reduced the excitatory action of N-methyl-D-aspartate (NMDA) to a greater extent than that of L-glutamate and the potency of this action was a half to a third that of D alpha AA. The DL-2-bromo derivative excited neurons, an effect greater than that of L-glutamate and not blocked by either D alpha AA or L-glutamic acid diethyl ester.
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