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  • Title: Opiate analgesics and endorphins inhibit rat dorsal root potential in vitro.
    Author: Suzue T, Jessell T.
    Journal: Neurosci Lett; 1980 Feb; 16(2):161-6. PubMed ID: 6133241.
    Abstract:
    The effects of endorphins and opiate analgesics on the dorsal root potential (DRP) were studied in vitro using the isolated spinal cord of newborn rat. Bath-applied beta-endorphin and [D-Ala2]-Met-enkephalinamide (D-Ala) greatly depressed the DRP and the depressant effects were abolished by prior perfusion with naloxone. The potency of Met-enkephalin, Leu-enkephalin and alpha-endorphin was much weaker than that of D-Ala. Morphine and levorphanol depressed the DRP and these effects were also antagonized by naloxone. The isolated rat spinal cord appears to be a convenient in vitro preparation for analysing the effects of opiates on synaptic transmission in the central nervous system.
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