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  • Title: The effect of decortication on the excitatory amino acid sensitivity of striatal neurones.
    Author: McLennan H.
    Journal: Neurosci Lett; 1980 Jul; 18(3):313-6. PubMed ID: 6133249.
    Abstract:
    Rat striatal neurones which are deprived of their cortical innervation become more sensitive to the excitatory actions of L-glutamate relative to kainate and probably to other amino acids. The density of sodium-independent binding sites for glutamate and kainate is unaltered. The enhanced glutamate sensitivity may be a 'denervation supersensitivity' since the corticostriate pathway is believed to be glutamate-mediated. It is argued that the cytotoxic effects of kainate are unlikely to involve receptors on the affected cells themselves.
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