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  • Title: Timolol maleate: side effects on healthy nonglaucomatous volunteers.
    Author: Davidson J, Ribak J, Eckstein D, Barishak R.
    Journal: Aviat Space Environ Med; 1983 Apr; 54(4):360-2. PubMed ID: 6133515.
    Abstract:
    As the number of military pilots over the age of 40 increases, open-angle glaucoma becomes an important aeromedical problem. Epinephrine ophthalmic solution is the only antiglaucomatotic agent in use among flying personnel. Timolol maleate, a new antiglaucomatotic agent, is a nonselective beta-blocker. This drug has a potent hypotensive effect on intraocular pressure with a minimal effect on visual functions. Our data show that it significantly decreases the pulse rate and may eventually be a basis for cardiac dysrythmias.
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