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  • Title: Effect of GABA and benzodiazepine antagonists on [3H]flunitrazepam binding to cerebral cortical membrane.
    Author: Fong J, Okada K, Lew JY, Goldstein M.
    Journal: Brain Res; 1983 Apr 25; 266(1):152-4. PubMed ID: 6133589.
    Abstract:
    The effects of GABA on the binding of [3H]flunitrazepam to bovine cerebral cortical membranes was investigated in presence and in absence of benzodiazepine antagonists. The percentage stimulation of [3H]flunitrazepam binding by GABA is higher when approximately 50% of the binding is displaced by benzodiazepine antagonists. The observed increase in percent stimulation of [3H]flunitrazepam binding by GABA might reflect the preferential displacement of the ligand by benzodiazepine antagonists from a GABA-insensitive conformational state or site of the receptor.
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