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  • Title: [Correlation of dopamin- and GABA-ergic mechanisms in the depressive effect of neuroleptics on pedal self-stimulation of the ventral tegmentum of the mesencephalon].
    Author: Talalaenko AN, Boreĭsha IK.
    Journal: Farmakol Toksikol; 1983; 46(2):36-9. PubMed ID: 6133777.
    Abstract:
    Inhibition of self-stimulation of the ventral tegmentum in male rats with droperidol, haloperidol, trifluoroperazine and chlorpromazine is realized by dopamin- and GABA-ergic mechanisms of the emotional-positive reinforcement system. The GABA-ergic rather than dopaminergic mechanisms of the positive reinforcement systems realize the fluphenazine-induced reduction of self-stimulation of the midbrain ventral tegmentum. Analogous effects of clozapine and thioridazine are realized outside the dopamin- and GABA-ergic mechanisms of the reinforcement system.
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