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  • Title: Imipramine does not act as a false transmitter in the rat hypothalamus.
    Author: Allen DL, Reith ME, Sershen H, Lajtha A.
    Journal: Brain Res; 1983 May 09; 267(1):161-4. PubMed ID: 6134569.
    Abstract:
    [3H]Imipramine was accumulated by rat hypothalamic slices mostly by a passive low-affinity process. Accumulated [3H]imipramine was released by 60 mM potassium, but the release was small and was not Ca2+-dependent. Imipramine induced some release of [3H]norepinephrine. None of these events were abolished by pretreatment of the rats with reserpine. These results do not favor the view that imipramine acts as a false transmitter in the rat hypothalamus. Rather, imipramine appears to be accumulated in an extragranular pool from which it releases extragranular norepinephrine.
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