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  • Title: A role for somatostatin in the impaired insulin secretory response to glucose by islets from aging rats.
    Author: Chaudhuri M, Sartin JL, Adelman RC.
    Journal: J Gerontol; 1983 Jul; 38(4):431-5. PubMed ID: 6134768.
    Abstract:
    The purpose of this study was to investigate a possible contribution by somatostatin to the impairment in glucose-stimulated secretion of insulin during aging. Pancreatic islets of Langerhans were isolated from male Sprague-Dawley rats aged 2- to 24-months and challenged in vitro with effectors of insulin secretion. Concentrations of insulin, glucagon, and somatostatin were determined by radioimmunoassay. The impairment of glucose-stimulated secretion of insulin which characterizes islets isolated from aged rats may be overcome by treatment of islets with antibodies to somatostatin. Enhanced availability and/or effectiveness of endogenous pancreatic somatostatin during aging may be responsible for the modified pattern of glucose-stimulated secretion of insulin.
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