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  • Title: [Action of dihydroergocristine at pre- and postsynaptic alpha-adrenoceptors in the rat isolated vas deferens].
    Author: Roquebert J, Demichel P, Gomond P, Malek A.
    Journal: J Pharmacol; 1983; 14(2):151-9. PubMed ID: 6134866.
    Abstract:
    1. The action of dihydroergocristine at pre- and postsynaptic alpha-adrenoceptors has been studied in the rat isolated vas deferens. 2. Postsynaptic alpha-adrenoceptor antagonist activity was assessed by comparing cumulative noradrenaline and phenylephrine dose-response curves in the absence and in the presence of increasing concentrations of antagonist. 3. Presynaptic alpha-adrenoceptor activity was assessed by studying the effects of drugs on contractions induced by electrical stimulation of the rat vas deferens. 4. At postsynaptic alpha-adrenoceptor dihydroergocristine antagonized the contraction induced by noradrenaline and phenylephrine with competitive mechanism (pA2 = 7.78 towards noradrenaline; pA2 = 7.76 towards phenylephrine). 5. At presynaptic alpha-adrenoceptors dihydroergocristine acts as partial agonist (pD2 = 5.70).
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