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  • Title: Analgesic actions of mu- and kappa-opiate agonists in rats.
    Author: Upton N, Sewell RD, Spencer PS.
    Journal: Arch Int Pharmacodyn Ther; 1983 Apr; 262(2):199-207. PubMed ID: 6135397.
    Abstract:
    The antinociceptive profiles of mu- and kappa-opiate agonists were determined in a combined tail immersion plus tail pressure nociceptive test in rats. Combined analysis of potencies for pressure against heat noxia enabled differentiation between all mu- and kappa-agonists tested, thus confirming previous studies in other animal species and paralleling observations from studies on isolated tissue preparations. The distinct antinociceptive profiles produced by mu- and kappa-agonists provide further quantitative evidence that these agents are behaviourally different.
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