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  • Title: [Racemic guanidinothiazoles with H2-antihistaminic activity. 13 H2-antihistaminics].
    Author: Spengler JP, Schunack W.
    Journal: Arzneimittelforschung; 1983; 33(3):377-80. PubMed ID: 6135427.
    Abstract:
    In studies on H2-antihistaminics with cyclic guanidine structure, side-chain branched racemic guanidinothiazoles were prepared and tested for their H2-antihistaminic activity on the isolated guinea-pig atrium. A simple synthesis of alpha-branched guanidinothiazoles is described. Of the prepared substances the racemic 14a, b in particular show high H2-antagonistic activity.
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