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  • Title: Short- and long-term changes in adrenal tyrosine hydroxylase activity during insulin-induced hypoglycemia and cold stress.
    Author: Fluharty SJ, Snyder GL, Stricker EM, Zigmond MJ.
    Journal: Brain Res; 1983 May 16; 267(2):384-7. PubMed ID: 6135493.
    Abstract:
    Insulin-induced hypoglycemia increases the capacity for catecholamine biosynthesis in the rat adrenal medulla by two temporally distinct processes: a rapid increase in the affinity of tyrosine hydroxylase (TH) for cofactor and a more gradual increase in the maximal TH activity. Cold exposure leads to comparable long-term increases in adrenal TH activity, apparently without causing a prior activation of TH.
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