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  • Title: Mechanism of action of phenylephrine on isolated guinea-pig atria rate.
    Author: Nigro D, Scivoletto R.
    Journal: Gen Pharmacol; 1983; 14(3):349-54. PubMed ID: 6135646.
    Abstract:
    1. Phenylephrine has a positive chronotropic effect on the right isolated guinea-pig atria and this effect is not modified by alpha-adrenergic blocker (phentolamine) but it is drastically inhibited by beta-adrenergic antagonists (practolol or propranolol). 2. The effect is substantially reduced by treatment with cocaine or pretreatment with reserpine. 3. Cocaine plus reserpine shift the dose-response curve for phenylephrine to the left. 4. It is concluded that positive chronotropic effect of phenylephrine has two components: direct action on beta-adrenergic receptors and an indirect action due to norepinephrine release.
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