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  • Title: In vivo release from cerebral cortex of [14C]glutamate synthesized from [U-14C]glutamine.
    Author: Thanki CM, Sugden D, Thomas AJ, Bradford HF.
    Journal: J Neurochem; 1983 Sep; 41(3):611-7. PubMed ID: 6135756.
    Abstract:
    Awake, unrestrained, and behaviourally normal animals with superfusion cannulae implanted over the sensorimotor cortex were used in a study of the capacity of infused [U-14C]glutamine for labelling glutamate and other amino acids released by depolarising stimuli. A spontaneous background release of [14C]glutamate was detected. This was increased by tityustoxin (1 microM). The specific radioactivity of glutamate increased eightfold during the evoked-release period. [14C]Aspartate was also detected and showed increased release, but not increased specific labelling, in response to depolarisation. Evoked gamma-aminobutyric acid (GABA) release occurred but only small amounts of [14C]GABA were detected. Glutamine showed increased rates of uptake to the sensorimotor cortex during stimulation periods, suggesting an accelerated breakdown via glutaminase.
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