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  • Title: [Oxidation of phenazepam in isolated hepatocytes from white rats].
    Author: Golovenko NIa, Meteshkin IuV, Kuznetsova SV.
    Journal: Vopr Med Khim; 1983; 29(3):49-53. PubMed ID: 6136125.
    Abstract:
    In isolated rat hepatocytes aromatic hydroxylation and oxidation of the 14C-phenazepame heterocycle were studied. Both these reactions proceeded with the linear rate in intact hepatocytes and aromatic hydroxylation predominated. After induction of cytochrome P-450 by phenobarbital the rate of the heterocycle oxidation was increased 3.6-fold. Rates of aromatic hydroxylation and the phenazepame heterocycle oxidation did not depend on administration of phenobarbital and 3-methyl cholanthrene into the animals. Effects of the factors studied (concentration of phenazepame, induction of cytochrome P-450 by means of phenobarbital and 3-methyl cholanthrene) on alterations in the rate of oxidation of both aromatic nuclei and the phenazepame heterocycle were estimated using dispersion analysis.
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