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  • Title: H1-histaminergic activation stimulates phosphatidylinositol labeling in rabbit aorta.
    Author: Villalobos-Molina R, García-Sáinz JA.
    Journal: Eur J Pharmacol; 1983 Jun 17; 90(4):457-9. PubMed ID: 6136415.
    Abstract:
    Histamine and 2-(2-aminoethyl)-thiazole induced dose-dependent increases in the labeling of phosphatidylinositol in rabbit aorta whereas impromidine was without effect. The effect of histamine was inhibited by antihistamines with the following order of potency: mepyramine greater than or equal to pyrilamine much greater than cimetidine. The data indicate that H1-histaminergic activation stimulates phosphatidylinositol labeling in rabbit aorta and suggest the involvement of a calcium-signaling process in the action of H1-histaminergic receptors.
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