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  • Title: Neuropeptide Y in phaeochromocytomas and ganglioneuroblastomas.
    Author: Adrian TE, Allen JM, Terenghi G, Bacarese-Hamilton AJ, Brown MJ, Polak JM, Bloom SR.
    Journal: Lancet; 1983 Sep 03; 2(8349):540-2. PubMed ID: 6136694.
    Abstract:
    Tumour tissue from nineteen patients with phaeochromocytomas and nine with ganglioneuroblastomas contained large numbers of neuropeptide Y (NPY) producing cells and extracts of these tumours had very high concentrations of immunoreactive NPY. Plasma NPY concentrations were also raised, averaging 460 pmol/l in patients with tumours of the sympathetic chain and 55 pmol/l in healthy controls. Since plasma NPY is straightforward to measure and relatively stable, its estimation may prove helpful as a screening tests for phaeochromocytoma.
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