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  • Title: Cholinergic effects of cimetidine and ranitidine.
    Author: Re L, Cingolani ML, Concettoni C, Rossini L.
    Journal: Pharmacol Res Commun; 1983 May; 15(5):485-517. PubMed ID: 6136992.
    Abstract:
    Cimetidine and ranitidine were submitted to eight in vitro assays: their intrinsic activity was evaluated on guinea-pig auricles and ileum, acetylcholine synergism on guinea-pig tracheal muscle, frog rectus abdominis, guinea-pig vas and rat phrenic nerve diaphragm, and antagonism on guinea-pig auricles and rat jejunum estimated at a range of concentrations. Ranitidine alone opposed 1-hyoscyamine antagonism in guinea-pig ileum when acetylcholine was the agonist, but not when the agonist was bethanechol.
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