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  • Title: A double blind comparison of alprazolam, diazepam and placebo in the treatment of anxious out-patients.
    Author: Davison K, Farquharson RG, Khan MC, Majid A.
    Journal: Psychopharmacology (Berl); 1983; 80(4):308-10. PubMed ID: 6137856.
    Abstract:
    The anxiolytic effects of alprazolam, a triazolobenzodiazepine, were evaluated in a double-blind 28-day comparison with diazepam and placebo in 46 out-patients suffering from anxiety states of moderate to severe intensity. Alprazolam 1.5-3 mg per day was found to be of at least equivalent anxiolytic effect to 15-30 mg diazepam per day, and there was evidence of antidepressant activity by alprazolam, but not diazepam, in neurotic depression. Side-effects occurred least often with alprazolam and were minor in nature. Laboratory data showed no changes attributable to alprazolam even in a patient who swallowed 15 capsules (7.5 mg). It was concluded that alprazolam is a safe and effective anxiolytic which is well-tolerated and also shows some antidepressant activity.
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