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  • Title: Central nervous system sites of action of bombesin and somatostatin to influence plasma epinephrine levels.
    Author: Brown MR.
    Journal: Brain Res; 1983 Oct 16; 276(2):253-7. PubMed ID: 6138126.
    Abstract:
    Bombesin acts within dog brain to increase plasma concentrations of glucose and epinephrine. Microinjection of bombesin into a variety of brain regions demonstrates that this peptide's site of action is within the dorsal hypothalamic area. Microinjection of the somatostatin analog, desAA1,2,4,5,12,13 [D-Trp8]-somatostatin (ODT8-SS) into the dorsal hypothalamic area but not into other brain areas prevents bombesin-induced elevation of plasma glucose and epinephrine. Thus bombesin and ODT8-SS act within specific brain areas to influence plasma concentrations of glucose and epinephrine.
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