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  • Title: Exclusion of cellular iron and reduced gamma-glutamyl transpeptidase activity in rat pancreas acinar cell hyperplastic nodules and adenomas induced by azaserine.
    Author: Mori H, Tanaka T, Takahashi M, Williams GM.
    Journal: Gan; 1983 Aug; 74(4):497-501. PubMed ID: 6138291.
    Abstract:
    Rat acinar cells in the azaserine-induced hyperplastic nodules or adenomas in the siderotic pancreas produced by repeated iron injections were found to be resistant to iron accumulation. These iron-resistant acinar cell lesions coincided rather well with the lesions having markedly decreased activity of gamma-glutamyl transpeptidase. These properties of the acinar cells could be useful for the identification of early lesions in pancreatic carcinogenesis.
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