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Title: Karabemycin, a new antimetabolite of glutamine produced by a strain of streptomycete. Author: Omura S, Nakagawa A, Aoyama H, Iwai Y, Kuwahara M, Furusato T. Journal: J Antibiot (Tokyo); 1983 Sep; 36(9):1129-35. PubMed ID: 6138342. Abstract: Karabemycin, a new peptide antibiotic, was isolated from the culture filtrate of Streptomyces sp. AM-6424, a soil isolate. The molecular formula of the antibiotic was determined as C15H24N4O6 on the basis of elemental analysis, FD-mass spectrum and 1H and 13C NMR. Acid hydrolysate of karabemycin contains one mol each of valine, alanine and an unknown amino acid. The antibiotic is active against Gram-positive and -negative bacteria on a synthetic medium. The inhibitory activity is reversed by L-glutamine and L-glutamic acid.[Abstract] [Full Text] [Related] [New Search]