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  • Title: Partial agonist effect of 2-[2-(1,4-benzodioxanyl)]-2-imidazoline (RX 781 094) at presynaptic alpha 2-adrenoceptors in rabbit ear artery.
    Author: limberger N, Starke K.
    Journal: Naunyn Schmiedebergs Arch Pharmacol; 1983 Sep; 324(1):75-8. PubMed ID: 6138716.
    Abstract:
    Ear arteries from rabbits were preincubated with 3H-noradrenaline and then perfused. 2-[2-(1,4-Benzodioxanyl)]-2-imidazoline (RX 781094) 0.1 or 1 microM reduced the overflow of 3H-noradrenaline and total tritium elicited by 13 electrical pulses at 0.25 Hz or 26 Pulses at 0.5 Hz. RX 781 094 1 microM increased the overflow elicited by 52 pulses at 1 Hz. The inhibitory effects were blocked by yohimbine 10 microM but not by prazosin 1 microM. The alleged antagonist RX 781 094 possesses intrinsic activity at the presynaptic alpha 2-autoreceptors of the ear artery.
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