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  • Title: Voltage clamp analysis of the effect of excitatory amino acids and derivatives on Purkinje cell dendrites in rat cerebellar slices maintained in vitro.
    Author: Crepel F, Dupont JL, Gardette R.
    Journal: Brain Res; 1983 Nov 21; 279(1-2):311-5. PubMed ID: 6139153.
    Abstract:
    A voltage clamp analysis of the effects of L-aspartate, L-glutamate and related derivatives on Purkinje cell dendrites was performed in rat cerebellar slices maintained in vitro. Short iontophoretic pulse applications of L-aspartate and L-glutamate in the dendritic field of Purkinje cells induced dose-dependent inward currents with fast onset and recovery. Quisqualate application also gave rise to well developed inward currents with fast onset and slow recovery, whereas N-methyl-D,L-aspartate had no or little effect on Purkinje cell membranes unless prolonged (several seconds) applications were used. Steady applications of low doses of N-methyl-D,L-aspartate much more severely depressed L-aspartate than L-glutamate mediated responses, whereas inward currents due to quisqualate were unaffected. Inward currents due to quisqualate were often more reduced than those due to L-aspartate by steady applications of 2-amino-5-phosphonovalerate, and the antagonistic action of this drug on responses due to L-glutamate was very weak. These results suggest that receptors of Purkinje cells for glutamate and aspartate are different, and are also different from N-methyl-D-aspartate and quisqualate receptors.
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