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  • Title: Pheochromocytoma resistant to alpha-adrenergic blockade.
    Author: Hauptman JB, Modlinger RS, Ertel NH.
    Journal: Arch Intern Med; 1983 Dec; 143(12):2321-3. PubMed ID: 6139989.
    Abstract:
    In a 54-year-old man with a norepinephrine-secreting pheochromocytoma, resistance developed to the alpha-adrenergic blocking agent, phenoxybenzamine hydrochloride. Dosages of 240 mg/day were ineffective. Intravenous phentolamine mesylate reduced his BP at first, but resistance developed to this also. Therapy with alpha-methylparatyrosine, an inhibitor of catecholamine biosynthesis, finally controlled his BP, and the tumor was removed.
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