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  • Title: Histamine H2-antagonists--past, present and future.
    Author: Brittain RT, Jack D.
    Journal: J Clin Gastroenterol; 1983; 5 Suppl 1():71-9. PubMed ID: 6140285.
    Abstract:
    In this selective review of histamine H2-antagonists, we emphasize the significance of burimamide, the first specific H2-antagonist, in physiology and pharmacology and describe how its discovery led to the development of cimetidine as a new treatment of acid-aggravated disease of the alimentary tract. Developments since cimetidine, include ranitidine, which is a more potent, selectively acting H2-antagonist. A new series of H2-blockers with prolonged activity is discussed, and exemplified, particularly AH 23844. Its prolonged action and its unusual, apparently insurmountable, blocking action is explained in fundamental physicochemical terms.
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