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  • Title: Serotonin uptake and efflux in blood platelets from untreated and neuroleptic-treated schizophrenics.
    Author: Lingjaerde O.
    Journal: Biol Psychiatry; 1983 Dec; 18(12):1345-56. PubMed ID: 6140960.
    Abstract:
    Earlier studies on platelet serotonin uptake in schizophrenia have given equivocal results. In this study, platelet serotonin uptake in diluted plasma was assessed in 23 drug-free and 19 neuroleptic-treated schizophrenics, compared to 70 controls. The maximal uptake rate, Vmax, was slightly but significantly lower in drug-free schizophrenics than in the controls. In neuroleptic-treated patients there was a nonsignificant trend in the same direction. The "affinity constant" Km was significantly elevated in neuroleptic-treated schizophrenics compared to both controls and drug-free patients. Assessment of serotonin uptake in platelets resuspended in an artificial medium gave no definite answer whether reduced Vmax in plasma is due to a plasmatic or a platelet abnormality. Spontaneous efflux of serotonin from preloaded platelets did not differ significantly between patients and controls.
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