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  • Title: Antagonism by tetrahydro-beta-carboline of the vasoconstrictor responses to tryptamine in rat tail arteries.
    Author: Hicks PE, Langer SZ.
    Journal: Eur J Pharmacol; 1983 Dec 09; 96(1-2):145-9. PubMed ID: 6141059.
    Abstract:
    Tryptamine and 5-HT mediate vasoconstriction in the isolated perfused rat tail artery. These agonists were differentiated by the classical serotonin receptor antagonists methysergide and ketanserin which were significantly more potent against 5-HT-induced responses. Neither prazosin nor RX 781094 alone or in combination reduced the vasoconstriction produced by tryptamine. Tetrahydro-beta-carboline (THBC) was devoid of agonist properties and behaved as a competitive antagonist of tryptamine but not of 5-HT. THBC also had alpha-adrenoceptor blocking properties in this preparation.
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