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  • Title: Response of brain and pituitary pools of dynorphin as compared to vasopressin to acute stress in the rat.
    Author: Millan MJ, Millan MH, Tsang YF, Herz A.
    Journal: Life Sci; 1983; 33 Suppl 1():29-32. PubMed ID: 6141491.
    Abstract:
    5 min foot-shock resulted in an elevation in levels of immunoreactive (ir)-dynorphin (DYN) and ir-vasopressin (VP) in the hypothalamus whereas their levels were not significantly modified in the neurointermediate pituitary. In the anterior pituitary, however, a fall in ir-DYN in the absence of any change in ir-VP was detected. Further, in the thalamus and medulla/pons, respectively, a decrease and increase in levels of ir-VP was observed whilst the content of ir-DYN therein was not significantly affected. These findings support the concept of a common origin and co-modulation of DYN and VP in the hypothalamic-neural lobe axis and that, extrinsic to this, DYN and VP are localized and modulated independently of each other.
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