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  • Title: Metabolism of proctolin, a pentapeptide neurotransmitter in insects.
    Author: Quistad GB, Adams ME, Scarborough RM, Carney RL, Schooley DA.
    Journal: Life Sci; 1984 Feb 06; 34(6):569-76. PubMed ID: 6141517.
    Abstract:
    The in vitro metabolism of [tyrosyl-3, 5-3H]proctolin (H-Arg-Tyr-Leu-Pro-Thr-OH) was studied in the following tissues from the American cockroach, Periplaneta americana: proctodeum, midgut, hemolymph, brain, terminal ganglion, and coxal depressor muscles. In all tissues assayed, the Tyr-Leu bond is the primary cleavage site, but scission of the Arg-Tyr bond is also significant. Greater than 90% of the degradative activity is found in the 100,000 X g supernatant from homogenates. In vivo studies with the tobacco hornworm, Manduca sexta, show that topically applied proctolin does not penetrate larval cuticle; proctolin is readily degraded to constituent amino acids (at least to Tyr) upon ingestion.
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