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  • Title: Lack of cholinergic deficit in the neocortex in Pick's disease.
    Author: Wood PL, Nair NP, Etienne P, Lal S, Gauthier S, Robitaille Y, Bird ED, Palo J, Haltia M, Paetau A.
    Journal: Prog Neuropsychopharmacol Biol Psychiatry; 1983; 7(4-6):725-7. PubMed ID: 6141615.
    Abstract:
    Choline acetyltransferase activity was decreased in the frontal cortex in Alzheimer's and Gerstmann-Straussler dementias but not in Pick's disease. Cortical somatostatin was only decreased in Alzheimer's dementia. Postsynaptic muscarinic binding sites appeared to be decreased in a subpopulation of Alzheimer's patients. Our data indicate that a loss of cholinergic innervation of the cortex is not common to all dementias.
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